Research Technician position in Cellular Senescence and Age-related Pathologies
European Research Institute for the Biology of Ageing (ERIBA)
The ERIBA is a newly established institute at the University Medical Center Groningen (UMCG). The central theme at the ERIBA is the molecular mechanism of (cellular) ageing. We aim to identify physiological and molecular changes that can explain the loss of cells and functional decline of cells and tissues with age. For this, we make use of state of the art technology and a variety of model organisms. Furthermore, we heavily invest in Systems Biology to integrate our findings in the various mechanisms of ageing that have been proposed. The ERIBA is housed in a brand new building and part of the central UMCG campus in central Groningen, a small (200,000 inhabitants) but vibrant city (with over 25,000 students) in the north of the Netherlands.
Cellular senescence is a complex tumor-suppressive mechanism induced by many different stresses. Senescent cells are characterized by growth arrest, changes in morphology and gene expression, and the secretion of inflammatory cytokines, proteases and other molecules that can alter the tissue microenvironment (a phenomenon termed the senescence-associated secretory phenotype or SASP). For an unknown mechanism, senescent cells increase with age, and are evident at sites of numerous age-related pathologies and pre-cancerous lesions. Recent results show that life-long elimination of senescent cells can prevent the development of certain age-related pathologies in a mouse model of segmental accelerated aging, strongly supporting the idea that senescent cells can be deleterious. In contrast, we and others have shown that the SASP might have a beneficial effect during tissue repair by promoting collagen degradation and differentiation of myofibroblasts. Thus, there is the possibility that senescence has been selected to ensure early life fitness (wound healing), but may have unselected deleterious effects late in life (aging and cancer promotion).
The Demaria lab is interested to dissect the molecular phenotypes of cellular senescence induced by different stimuli using animal models. In particular, we will use different aging and cancer models.
We are looking for a committed and enthusiastic research technician that can support our animal work by managing breeding, experimental planning and help scientists with daily tasks. Recent master graduates are also encouraged to apply, and might apply for PhD student positions at the end of the contract.
Wat vragen wij
- Excellent record of work with mouse models and managing mouse colonies.
- Individuals with article 9 or 12 qualifications for animal testing will be prioritized.
- Experience in a wide variety of molecular and cellular biology techniques (e.g. qPCR, FACS, Western blots, histology, cell culture).
- Should be enthusiastic, ambitious, and organized.
- Collaborative, communication and networking skills are mandatory.
- Good knowledge of English.
The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.
In case of specific professions a ‘Certificate of Good Conduct’ is required.
Wat bieden wij
Your salary will be a maximum of € 3.184,- gross per month (scale 7), depending on your qualifications and relevant experience, based on a full-time appointment. In addition, the UMCG will offer you 8% holiday pay, and 8.3% end-of-year bonus.
The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC). English: http://www.nfu.nl/english/about-the-nfu/
Employment basis: Temporary for specified period (36 hours a week).
Duration of the contract: 2 years (1 + 1) with possibility for further extensions.
For more information please contact Dr. Marco Demaria, team leader of the laboratory, e-mail: firstname.lastname@example.org (please do not use e-mail address for applications), or click here.
Please use the the digital application form at the bottom of this page - only these will be processed. You can apply until 8 March 2020.
Full applications including a motivation letter, your resume and two contacts for reference letters will receive full consideration.
Within half an hour after sending the digital application form you will receive an email- confirmation with further information.