PhD position in structural virology
Faculty of Science and Engineering
Rijksuniversiteit Groningen, University of Groningen, V23.0765
The PhD candidate will be performing research at the interface of virology, structural biology, and drug design using state-of-the art protein crystallography and/or single-particle cryogenic electron microscopy (cryo-EM). There is plenty of space for an enthusiastic candidate to tailor their projects based on their interests. The candidate will be working in a highly international, multidisciplinary environment consisting of synthetic chemists, structural biologists, virologists, and cell biologist allowing for an effective and cooperative methodological and topical exchange.
PhD project on structurally and biochemically characterising proteins involved in the viral hijacking of mitochondrial function
Viruses have evolved sophisticated methods to hijack host cell functions to benefit replication. Some of the most important cellular processes are tightly linked to mitochondrial function, such as cellular homeostasis, metabolism, and innate immunity. Especially for the latter viral genomes encode for proteins that prevent proper innate immune signalling allowing for the virus to replicate. Among these mechanisms is the prevention of the intrinsic apoptosis pathway, which is triggered upon a viral infection, by expressing viral Bcl-2 homologues. The candidate will use a highly integrative structural biology approach to structurally and biochemically characterise these proteins and use bottom-up drug discovery approaches to identify novel small molecule compounds that can prevent the function of these viral proteins. The candidate will be trained in prokaryotic and/or eukaryotic recombinant protein expression, macromolecular x-ray crystallography, cryo-EM, biophysical methods, and classical virology experiments.
The vacancy is at the Department of Molecular Pharmacology, (Primary Supervisor: Assistant Professor Dr Karim Rafie: https://www.rug.nl/staff/k.rafie/?lang=en), Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen. The research of Dr Rafie is aimed at elucidating the precise structural and molecular mechanisms of how viruses co-opt host cell mechanisms to benefit replication and to use this knowledge to develop novel antivirals. We offer a stimulating research environment for PhD students interested in structural biology, structure-guided drug development, protein biochemistry as well as cell biology, and virology. The department’s research laboratories are well equipped for molecular biology, protein biochemistry, and tissue culture work. In addition, local access to an X-ray generator and cutting-edge cryo-EM facility is provided.
The University of Groningen (founded in 1614) has a long tradition of academic excellence, being one of the oldest research universities in Europe. The University is currently in or around the top 100 on several influential ranking lists. Currently approximately 34,000 students are enrolled and about 1,500 PhD students work on their theses. It has a highly international character: English is the main language in the research laboratories. The city of Groningen is a historic town and among the ten biggest cities in The Netherlands. It is a vibrant student town with a direct train connection to Schiphol Airport near Amsterdam.
We are looking for an enthusiastic and talented PhD candidate with a Master of Science (MSc) degree in chemistry, biotechnology, biochemistry, virology or related, and with outstanding laboratory skills. Experience with structural biology methods is a plus but not essential.
You are expected to be fluent in the English language (written and oral). Important personal skills include the ability to collaborate and work in an international team, bring a high motivation, and have the ability for inter- and multidisciplinary thinking and good social skills.
Conditions of employment
Contract length: 48 months.
We offer you in accordance with the Collective Labour Agreement for Dutch Universities:
• a salary of € 2,770 (salary scale PhD candidates) gross per month in the first year, up to a maximum of € 3,539 gross per month in the fourth and final year, based on a full-time position
• a holiday allowance of 8% gross annual income an 8.3% year-end bonus
• a temporary position of one year with the option of renewal for another three years; prolongation of the contract is contingent on sufficient progress in the first year to indicate that you will successfully complete your PhD thesis within the next three years. A PhD training programme is part of the agreement.
The preferred starting date is between April and June 2024
Required documents are: • letter of motivation including a statement of your research interests, relevant skills and experience, as well as an explanation of your reasoning to apply to the advertised position • a Curriculum Vitae • certified records of a completed MSc and explanation of international grades • names and email addresses of at least two academic references willing to write confidential letters of recommendation. You may apply for this position until 14 January 11:59pm / before 15 January 2024 Dutch local time (CET) by means of the application form (click on "Apply" below on the advertisement on the university website). Shortlisted candidates will be informed end of January/beginning of February 2024. The University of Groningen strives to be a university in which students and staff are respected and feel at home, regardless of differences in background, experiences, perspectives, and identities. We believe that working on our core values of inclusion and equality are a joint responsibility and we are constructively working on creating a socially safe environment. Diversity among students and staff members enriches academic debate and contributes to the quality of our teaching and research. We therefore invite applicants from underrepresented groups in particular to apply. For more information, see also our diversity policy webpage: https://www.rug.nl/about-ug/policy-and-strategy/diversity-and-inclusion/ Our selection procedure follows the guidelines of the Recruitment code (NVP): https://www.nvp-hrnetwerk.nl/nl/sollicitatiecode and European Commission's European Code of Conduct for recruitment of researchers: https://euraxess.ec.europa.eu/jobs/charter/code Unsolicited marketing is not appreciated.
For additional information, please contact:
Dr K. Rafie
In your application, please always include the job opening ID V23.0765