PhD student position in stem cell radiobiology of FLASH radiation therapy

Department

Radiotherapie

Working Enviroment

Within the UMCG PARticle Therapy REsearch Center (PARTREC), which is embedded in the Departments of Radiation Oncology and Biomedical Sciences of Cells and Systems of the University Medical Center Groningen (UMCG) in the Netherlands, we are looking for a highly motivated and ambitious PhD student a (medical) biologist with expertise in (stem) cell biology, molecular biology, radiation biology or similar.

The successful candidate will join our labs and contribute to improving our biological knowledge on the mechanism, effectiveness and clinical applicability FLASH therapy with proton beams. The project is funded by grants provided by IBA and Nirty Holland PPP. The research project is headed by Prof. Dr. Rob Coppes, whose group’s main research interest is the study of the role of stem cells in tumor radiation response and normal tissue regeneration. His lab developed several organoids and other pre-clinical models to study radiation responses.

Job description

Currently there is increasing interest in FLASH radiation therapy, which may be a paradigm-shifting new method for delivering a high dose of radiation at an ultra-high dose rate (>40Gy/s). The technique has been suggested to protect normal tissues while maintaining anti-tumour efficacy equivalent to that of conventional radiation therapy at similar dose levels.

The successful applicant will investigate the mechanism and effectiveness of Proton FLASH using different models in vitro, such as tumor and normal tissue organoids and in vivo models. Focus will be on mammary gland tumors and surrounding normal tissues. We are looking for a highly motivated and ambitious PhD student with a background in (stem) cell biology, molecular biology, radiation biology or similar.

Requirements

We are looking for an excellent, highly motivated candidate with strong background in cellular biology, preferably in stem cell and/or radiation biology. Additional experience in molecular biology, biochemistry, bioinformatics, cultures of human cells and organoid techniques would be favorable.

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.

In case of specific professions a ‘Certificate of Good Conduct’ is required.

Conditions of employment

It concerns a fulltime appointment (36 hours a week) for a period of four years to be concluded with a PhD examination. After one year, the performance of the candidate will be evaluated to decide whether there is sufficient progress to expect a successful completion of the PhD thesis within the coming three years.

Your salary will be a minimum of € 2.631,- gross per month in the first year and a maximum of € 3.336,- gross per month (scale PhD) in the final (4th) year, based on a full-time appointment. In addition, the UMCG will offer you 8% holiday pay, and 8.3% end-of-year bonus. The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

Additional information

For more information about this vacancy you may contact:

Prof. Dr. Rob Coppes telefoonnummer +31 50 361 6124
r.p.coppes@umcg.nl
Dr. Peter van Luijk
p.van.luijk@umcg.nl

Applying for a job

Please use the the digital application form at the bottom of this page - only these will be processed. You can apply until 15 September 2022. Within half an hour after sending the digital application form you will receive an email- confirmation with further information.

Digital application form