PhD student ‘ Delivery of therapeutic agent to the brain for multiple sclerosis’
Dept. of Cell Biology and Dept. of Biomedical Engineering
The project is a joined project of the Department of Cell Biology and the Department of Biomedical Engineering at the University Medical Center Groningen, the Netherlands.
The Department of Cell Biology focuses on post-transcriptional responses to cellular and metabolic stress centered around the themes cellular fitness and human health (http://cellbiology.umcg.nl). The Department runs facility centers for Drosophila research and advanced microscopy and participates in the Multiple Sclerosis Center Noord Nederland (MSCNN) as wells as in several recognized centers of expertise for rare diseases.
The Department of Biomedical Engineering focuses on biomedical materials science and its application. The use of biomaterials, ranging from (macroscale) implants to (nanoscale) drug carrier systems, is studied by multidisciplinary research at the interface between physical chemistry, microbiology, cell biology and medicine. The Department runs a.o. a facility center for atomic force microscopy (AFM).
Loss of central nervous system (CNS) myelin and failure of remyelination contribute to the functional impairment that characterizes the demyelinating disease multiple sclerosis (MS). As incomplete remyelination will irreversibly damage axonal connections, therapies that effectively promote remyelination are necessary to prevent worsening of the disease. Recently, we identified a promising therapeutic agent to induce remyelination. This project concerns the clinical translation of this finding that requires the development of nanocarriers for delivery of the therapeutic agent across the blood-brain barrier. To mimic the disease, MS-patient specific in vitro models using patient-derived induced pluripotent stem cells (iPSCs) will be used.
The position is funded by the Dutch MS Research Foundation
The candidate should have a Master’s degree in (Cell) Biology, Biomedical Engineering, Neuroscience or Chemistry, good oral and written skills in English, team player mentality, and a pro-active and flexible work attitude. Experience with animal models and primary cultures (iPSCs) is strongly preferred.
The UMCG has a preventive Hepatitis B policy. You may be required to build up sufficient protection against Hepatitis B before you can be appointed. Vaccination is provided by the UMCG if necessary.
Conditions of employment
It concerns a fulltime appointment for a period of four years to be concluded with a PhD examination. After one year, the performance of the candidate will be evaluated to decide whether there is sufficient progress to expect a successful completion of the PhD thesis within the coming three years.
The UMCG offers a salary of € 2.266,- gross per month in the first year, up to a maximum of € 2.903,- gross per month in the last year. In addition, the UMCG will offer you 8% holiday pay, an 8.3% end-of-year bonus and a development budget.
The terms of employment comply with the Collective Labour Agreement for Medical Centers (CAO-UMC).
For more information please contact
Dr. W. Baron, email@example.com, +31503616116
Dr. I.S. Zuhorn, firstname.lastname@example.org, +31503616178
(Please do not use email adresses for applications)
Applying for a job
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You can apply until 9 July 2017.
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