Post-doc in cancer biology: “targeting replication stress in cancer cells”
Department of Medical Oncology
We have an exciting opportunity for a post-doctoral researcher, funded by the European Research Council (ERC). The position will be initially for 1 year, with the possibility of extension for 3 years. The position is available in the research group of prof. Marcel van Vugt, which is focused on cell cycle regulation and DNA damage responses in the context of cancer. The research group is embedded in the Department of Medical Oncology of the University Medical Center Groningen (UMCG) in the Netherlands, where oncological patient care is coordinated with preclinical and fundamental research on the biology and treatment of cancer. The lab is surrounded by other labs that study chromatin biology and genome instability. More information on current research topics can be found on our website: www.vanvugtlab.com
You will work on a project aiming to elucidate how cancer cells can cope with high levels of replication stress. A characteristic of many cancers is their high degree of genomic instability, which is thought to be fueled by replication stress. In this project, which is funded by a recently awarded ERC consolidator grant, we aim to unravel how oncogene-induced replication stress is resolved throughout the cell cycle, with a particular focus on mitosis. You will use biochemical microscopy and genetic approaches. Within this project, we, will ultimately validate our findings in patient material and ex vivo cultures of primary tumor material.
Heijink AM et al. A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity. PNAS 2015. 8;112(49):15160-5.
Hengeveld RC et al. Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability. Dev Cell. 2015. 34(4):466-74.
Fehrmann RS et al. Gene expression analysis identifies global gene dosage sensitivity in cancer. Nat Genet. 2015. 47(2):115-25.
Lafranchi L et al. APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage. EMBO J. 2014. 33(23):2860-79.
We are looking for an enthusiastic post-doc to be part of our multidisciplinary research group. The candidate should have the following requirements:
- PhD in Medical/Molecular Biology.
- Fluent in English, both spoken and written.
- Extensive experience in molecular and cell biology techniques (cell culture, DNA cloning, microscopy).
- A proven track-record in molecular/cell biology, preferably in the field of cell cycle or DNA damage signaling.
- An enthusiastic, ambitious team player.
Conditions of employment
- A full-time contract (36 hours/week) for initially 1 year, possible extended for an additional 3 years.
- Based on qualifications and experience, a maximum salary of € 4.152,- (scale 10) gross a month will be offered.
- The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).
- In addition, the UMCG will offer you 8% holiday pay, an 8.3% end-of-year bonus and a development budget.
The UMCG has a preventive Hepatitis B policy. You may be required to build up sufficient protection against Hepatitis B before you can be appointed. Vaccination is provided by the UMCG if necessary.
For more information about this vacancy you may contact: prof. Marcel van Vugt, PhD, firstname.lastname@example.org (for inquiries only, please do not use for applications).
Applying for a job
Please use the the digital application form at the bottom of this page - only these will be processed.
You can apply until 31 October 2016.
Immediately after sending the digital application form you will receive an email- confirmation with further information.
Digital application form