PhD positions Single-molecule protein sequencing and analysis with nanopores

Department

Faculty of Mathematics and Natural Sciences

Organisation

University of Groningen

Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative institution of higher education offering high-quality teaching and research. Flexible study programmes and academic career opportunities in a wide variety of disciplines encourage the 30.000 students and researchers alike to develop their own individual talents. As one of the best research universities in Europe, the University of Groningen has joined forces with other top universities and networks worldwide to become a truly global centre of knowledge.

Two PhD positions investigating the physical and chemical properties of nanopores are available in the laboratory of Prof Giovanni Maglia in the department of Chemistry and Biotechnology of the University of Groningen, The Netherlands.

Job description

Biological nanopores are an exciting new class of biosensors, which main practical application is in single-molecule sequencing and single-molecule analysis. We are looking for talented and motivated students who are willing to engage in a PhD programme in any of the following subjects:

DE NOVO DESIGN OF NANOPORES. In collaboration with the Molecular Dynamics Group at the University of Groningen the candidate will use molecular dynamic simulations in combination with advanced chemical and biochemical techniques to design nanopores with targeted diameter, shape and function.

PROTEIN SEQUENCING. As part of a consortium that includes researchers from Delft and Wageningen, the candidate will develop, engineer and re-design biological nanopores that will allow the sequence identifications of proteins as they are translocated across a nanopore. This will be the first technology that will be able to identify and sequence proteins at the single-molecule level.

Requirements

The candidate should hold a master’s degree in Chemistry, Chemical Biology, Biochemistry or Biotechnology or equivalent.

Expertise in molecular biology (recombinant DNA techniques, protein expression and purification), chemical modification of proteins or peptides, MD simulations will be an advantage, but not a limiting factor.

Conditions of employment

Contract length: 48 months.

The University of Groningen offers a salary of € 2,191 gross per month in the first year up to a maximum of € 2,801 gross per month in the fourth year. It is a temporary assignment for a period of four years. First, you will get a temporary position of one year with the perspective of prolongation with another three years. Before the end of the first year, there will be an evaluation as to the feasibility of successful completion of the PhD thesis within the next three years.

The preferred starting date is as soon as possible.

Application
You may apply for this position until 14 August / before 15 August 2017 Dutch local time by means of the application form (click on "Apply" below on the advertisement on the university website).

Unsolicited marketing is not appreciated.

Additional information

For additional information, please contact:

Dr Giovanni Maglia
g.maglia@rug.nl

In your application, please always include the job opening ID 217211-12

Extra informatie kan worden verkregen via een van de volgende links:

Maglia Lab

Digital application form