PhD student on molecular analysis of novel genes in epidermolysis bullosa

Department

Dermatology

Working Enviroment

The Department of Dermatology of the UMCG is specialized in genetic skin diseases, and the hereditary skin fragility disorder epidermolysis bullosa (EB) in particular. Our department is the single specialized EB center in the Netherlands and every patient with this disease is seen here. Apart from the clinics, the department of Dermatology has a laboratory of its own providing the possibility to perform translational research. The clinical severity of EB varies from early post-natal lethality to very mild with few morbidity. Till now mutations in 19 different genes have been found causative for EB. With novel mutation analysis techniques we recently discovered novel genes involved in EB. The proteins involved have not been characterized functionally and structurally in the skin. Furthermore, they are expressed in the heart as well. We have a well running collaboration with the Genetics and Cardiology departments in the UMCG, as well as the EB centers abroad (Germany, France, UK, Austria).

Job description

The aim is to functionally and structurally characterize the novel discovered genes involved in EB in skin and heart. This will provide us with knowledge about the normal function of these tissues, as well as, most important, provide the patient with information about his diagnosis and prognosis.
We are looking for a motivated PhD student who is capable of adopting novel laboratory techniques for DNA, RNA and protein analysis. The connection with the clinical phenotype is always present and you will also work with patient material. Furthermore, animal studies (zebrafish, mouse models) will be required.

Requirements

- M.Sc. in bio-molecular sciences, medical biology or related area
- Inquisitive and independant research attitude
- Curiosity for the translational part
- Willingness to work with animal models, experience in this area is appreciated

The UMCG has a preventive Hepatitis B policy. You may be required to build up a sufficient protection against Hepatiitis B before you can be appointed. Vaccination is provided by the UMCG if necessary.

Conditions of employment

The PhD project is funded by a grant and can provide a minimum of three years fulltime appointment (36h p/w) for the candidate. The project is concluded with a PhD examination. After one year, the performance of the candidate will be evaluated to decide whether there is sufficient progress to expect a successful completion of the PhD thesis.

Your salary is € 2.266,- gross per month in the first year up to a maximum of € 2.770,- gross per month in the third year (scale PhD). In addition, the UMCG will offer you 8% holiday pay, an 8.3% end-of-year bonus and a development budget. The terms of employment comply with the Collective Labour Agreement for Medical Centers (CAO-UMC).

More information
For more information about his vacancy you may contact:
Prof. dr. M.F. Jonkman, dermatoloog e-mail: m.f.jonkman@umcg.nl
Dr. M.C. Bolling, dermatoloog e-mail: m.c.bolling@umcg.nl
(please do not use emailadresses for applications)

How to apply
Full applications including a resume (curriculum vitae), a motivation letter and the names of two references will receive full consideration.
Please use the the digital application form at the bottom of this page - only these will be processed.
You can apply until 12 September 2017.
Immediately after sending the digital application form you will receive an email- confirmation with further information.

Additional information

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